Document Type

Thesis

Date of Award

1977

Degree Name

Master of Arts (MA)

Department

Biological Sciences

First Advisor

Alex Shrift

Second Advisor

Fredrick Kull

Third Advisor

Bruce Norcross

Series

Science and Mathematics

Abstract

This thesis was undertaken in order to gain a more complete understanding of the penetration of the sulfur metabolic pathways by selenium. Specifically, an attempt was made to determine if selenium could replace sulfur in biotin synthesized by Phycomyces blakesleeanus. Although selenium has been found to replace sulfur in many biologically active compounds, it has never been demonstrated in a naturally synthesized coenzyme or cyclic structure such as that found in biotin.

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