Drug addiction susceptibility results from many individual factors, one of which is genetic variation. Impulsivity, defined as rash or uncontrolled reward pursuit and consumption, is itself a genetically influenced trait that positively correlates with an individual’s likelihood of developing a substance use disorder. The BXD recombinant inbred mouse panel is a powerful tool that allows for assessments of genetic correlations between phenotypes and the heritability of such behaviors. Six strains of BXD mice have been selected based on low or high impulsive action in a previous reversal learning study. Male and female mice underwent reversal learning testing. Total trials to criteria (impulsive action), premature responding, trial initiation time, trial omissions, and reward retrieval time was recorded. That data showed a main effect of strain and impulsivity level for impulsive action, trial omissions, and reward retrieval time and heritability estimates were derived, while no effect of sex was observed. The different behavioral measures will have correlations conducted to understand heritable impulsive behavior in mice. This will contribute to future analysis of underlying neural influences on the behavior, including dopamine transmission within the orbitofrontal cortex and nucleus accumbens, in these animals.
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DeMarco, Lauren; Bailey, Lauren; and Jentsch, David, "Examining Role of Impulsive Action in BXD Mice to Understand Heritability in Drug Addiction" (2022). Research Days Posters 2022. 91.