Publication Date


Document Type



Fetal Alcohol Spectrum Disorder is an umbrella term that describes the host of symptoms that may result from prenatal alcohol exposure (PAE). The incidence of anxiety disorders in children exposed to moderate PAE (mPAE) is twice that seen in children exposed to low amounts. mPAE animal models demonstrate anxiety-like behaviors reflective of those seen in humans exposed to mPAE. Gestational day 12 (G12) in rats is a period during which the amygdala is undergoing significant development. Past studies suggest that mPAE during G12 is implicated in the anxiety-like behavior observed in rats. The basolateral amygdala is part of the anxiety circuit and is modulated by the dynorphin/kappa opioid receptor (KOR) system. This study aims to measure KOR expression levels following mPAE on G12 to determine how these changes contribute to anxiety-like behavior observed in rats. Ongoing experiments are assessing alterations in KOR mRNA levels using RNAscope in situ hybridization.



Download Full Text (1.4 MB)

The Effects of Moderate Prenatal Alcohol Exposure on Kappa Opioid Receptor Expression Across Development in Rats