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Current treatments for Obsessive Compulsive Disorder (OCD) are ineffective. This study evaluated the neo-clomipramine (neoCLOM) animal model of OCD using elevated plus maze (EPM) testing and HPLC analysis of dopamine (DA) and norepinephrine (NE) in punches of the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC). Treatment had an effect on total arm entries, whereas Sex had an effect on open arm entries: (a) neoCLOM females had increased total arm entries compared to neoSAL females; (b) both female groups had more closed and total arms entries compared to respective male groups; (c) neoCLOM females spent more time in the open arms compared to neoCLOM males. The hyperlocomotion exhibited by the females in the EPM suggests alternative interpretations of female expressions of anxiety in the EPM may be needed. HPLC analysis showed that both NE and DA levels in the ACC and OFC were affected by Treatment and Sex. Although traditional interpretation of behaviors in the Elevated Plus Maze do not support the face validity of the neoCLOM model, promise for the construct validity of the neoCLOM model is suggested by the increased levels of NE and DA in the orbitofrontal and anterior cingulate cortices.



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Sex Influences Behaviors and Neurochemistry of the Neonatal Clomipramine Model of Obsessive-Compulsive Disorder (OCD)