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This study examined a novel animal model of OCD, the neoCLOM model, in which rats are treated twice daily from postnatal Days 9-16 with 15 mg/kg of the serotonin-norepinephrine uptake inhibitor clomipramine. Results showed there was an effect of neonatal TREATMENT on levels of norepinephrine (NE) measured from micropunches of post-mortem brain tissue using High Performance Liquid Chromatography. Compared to control males, neoCLOM males had higher levels of NE in the amygdala and the lateral thalamus. Compared to control females, neoCLOM females had higher levels of NE in the motor cortex, orbitofrontal cortex, and the hypothalamus. There was also an effect of SEX. Versus control males, control females had higher levels of NE in the lateral thalamus, ventral striatum, and anterior cingulate cortex. Conversely, levels of NE in the hypothalamus were lower in the control females versus males. Compared to neoCLOM males, neoCLOM females had higher levels of NE in the prefrontal cortex and the motor cortex. SEX (but not treatment) had a significant effect on corticosterone levels (rat analog of cortisol) in post-mortem trunk blood. The current finding that the elevation of NE evidenced in OCD was mirrored by increased levels of NE in brain structures of the neoCLOM rats adds support for the validity of this new animal model.



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Norepinephrine and Corticosterone in the neoCLOM Animal Model of Obsessive Compulsive Disorder: Effects of Treatment and Sex