Author ORCID Identifier
https://orcid.org/0009-0008-7366-8630
Document Type
Article
Publication Date
Spring 2024
Keywords
Hedgehog pathway, Protein pathway, Anencephaly, Polydactyly, Congenital disorders, Birth defects, GLI3, Neural tube defect, WDR34, Smoothened agonist
Department
BIOLOGICAL SCIENCES
Abstract
The Hedgehog pathway is a fundamental signaling pathway in the human body; involved in carcinogenesis, stem cell maintenance, as well as limb patterning in embryonic development. Originally discovered in drosophila, their initial discovery, and subsequent analysis revealed many novel pieces of information about the mechanisms inside the human body, as many core components of the signaling pathway are carried over from fruit flies to humans. Because of the key roles hedgehog signaling plays in human development, dysfunction and mutations in the pathway can be detrimental. This review will focus on two congenital birth defects thought to be caused by hedgehog signaling dysfunction; anencephaly, and polydactyly. Both disorders that produce notable effects on the human body, but yet have differing manifestations and severities.
Recommended Citation
Towery, Joshua, "Hedgehog Signaling and Congenital Disorders; the Case of Anencephaly and Polydactyly" (2024). First-Year Research Immersion (FRI) Scholarship. 2.
https://orb.binghamton.edu/fri_scholarship/2
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Included in
Biochemistry Commons, Biology Commons, Medical Biochemistry Commons
Comments
Done as a part of the FRI Biomedical Chemistry program under leadership of Dr.Zihan Xu