Author ORCID Identifier
Date of Award
Chemistry (BA, BS)
Dr. Chuan-Jian Zhong
Science and Mathematics
Gold -- Diagnostic use ; Volatile organic compounds -- Detection ; Lungs -- Cancer -- Detection
Lung cancer is one of the most common and fatal cancers today, infecting 1 in 16 people, and killing well over a million patients per year. Currently, lung cancer is detected usually in stages three and four by quite costly and invasive methods, which shows only a survival rate of 10%. Breath sensors provide a low-cost and non-invasive technique for early screening of lung cancer. The breath sensors use assemblies of gold nanoparticles to identify lung cancer, specifically by identifying and quantifying specific volatile organic compound (VOC) concentrations found in the breath of lung cancer patients. This thesis describes a study of the synthesis and preparation of gold nanoparticle sensing films for breath sensor application. The objective of this work is to develop stable composite sensing films with gold nanoparticles of a few nanometer sizes synthesized via chemical reduction and characterize them using TEM and UV/Vis spectroscopy. The nanocomposite materials promote long-term stability and display sensitive responses to VOCs. The breath sensors are promising for identifying the concentration of VOCs in future use as a diagnostic tool.
Mercer, Tara, "Synthesis and characterization of nanocomposite sensing films for breath sensors" (2023). Undergraduate Honors Theses. 24.