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Author ORCID Identifier

https://orcid.org/0000-0002-6410-1375

Abstract

In this article we explore and validate the utility of an unsupervised probabilistic model, Gaussian Latent Dirichlet Allocation (GLDA), for discovering discrete states from repeated, multimodal psychophysiological samples collected from multiple individuals. Psychology and medical research heavily involves measuring potentially related but individually inconclusive variables from a cohort of participants to derive diagnosis, necessitating clustering analysis for state identification. Traditional probabilistic clustering models such as Gaussian Mixture Model (GMM) assume a global mixture of component distributions, which may not be realistic for observations from different patients. The GLDA model borrows the individual-specific mixture structure from a popular topic model Latent Dirichlet Allocation (LDA) and merges it with the Gaussian component distributions of GMM to suit continuous type data. We implemented GLDA using STAN and applied it on two datasets, one containing ecological momentary assessments and the other heart measures from electrocardiogram and impedance cardiograph. We found that in both datasets the GLDA-learned class weights achieved significantly higher correlations with clinically assessed depression, anxiety, and stress scores than those produced by the baseline GMM. Our findings demonstrate the advantage of GLDA over conventional finite mixture models for human state discovery from repeated multivariate data, likely due to better characterization of potential underlying between-participant differences.

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